HIV Type 1 Intersubtype Recombinants during the Evolution of a Dual Infection with Subtypes B and G

• DOI: 10.1089/aid.2007.0230
• Publication Date: 2008-02-19T13:53:40Z
• Authors: Mercedes Muñoz-Nieto; Lucía Pérez-Álvarez; Miguel Thomson; Valentina García; Antonio Ocampo; Gema Casado; Elena Delgado; Celia Miralles; Elena V´zquez de ...; María Sierra; Gerardo Contreras; Rafael Nájera
• Keywords: Breakpoint

The aim of this study was to characterize the HIV-1 intersubtype recombinant forms generated during follow-up a dual natural infection with subtypes B and G. Near full-length sequences from plasma peripheral blood mononuclear cell (PBMC) compartments were analyzed biological characteristics their derived primary isolates studied. Different mutations detected in V1, V2, V3 but not RNA or PBMC DNA. near sequence first collected subtype G presence subpopulations observed subtype-specific primers for protease reverse transcriptase segments. Subsequent plasma, PBMCs, obtained 6 years; all them BG recombinants showed identical breakpoints between pol nef. env harbored unique insert B. Specific loop identified fluctuating and/or either