Identification of a new HIV Type 1 Circulating Recombinant Form (CRF38_BF1) in Uruguay

• DOI: 10.1089/aid.2008.0248
• Publication Date: 2009-03-30T17:20:06Z
• Authors: Dora Ruchansky; Concepción Casado; José C. Russi; Juan R. Arbiza; Cecilio Lopez-Gal...
• Keywords: Identification

Recombination has been shown to be an important force in HIV-1 evolution. contributes increase genetic variation and hinders vaccine design efforts. Several molecular epidemiology studies South America described the circulation of subtypes B, F, C as well several B/F1 recombinants. This study performed by nucleotide sequencing at least two genes 89 samples from Uruguay a complex epidemic characterized cocirculation subtype strains, together with group BF1 recombinant viruses, including isolates similar CRF12_BF. In addition we identified new circulating form, designated CRF38_BF(1), which was dominant virus group.