The Application of Proteomics and Genomics to the Study of Age-Related Neurodegeneration and Neuroprotection

• DOI: 10.1089/ars.2007.9.169
• Publication Date: 2006-12-07T14:52:54Z
• Authors: Orly Weinreb; Noam Drigues; Yotam Sagi; Abraham Z. Reznick; Tamar Amit; Moussa B.H. Youdim
• Keywords: Peroxiredoxin

The present study aimed to acquire more information on aging-related alterations, using proteomic and genomic analyses of hippocampus from young (8 months) old (27 rats. In the rats, analysis identified changes in proteins related iron-mediated oxidative stress (OS) pathway, including reduction antioxidant enzymes (e.g., peroxiredoxin, cytochrome c oxidase) induction ferritin. Furthermore, neurofilament light peptide, associated with neurodegenerative processes, was enhanced binding/ chaperone were altered vs. At genes levels, significant molecular neurodegeneration aged rat hippocampus. Thus, effects potent neuroprotective compounds, anti-Parkinson drug, rasagiline anti-Alzheimer ladostigil (1 mg/kg, for 30 days) gene expression further investigated. Both drugs reversed effect aging various mitochondrial key regulator involved neurodegeneration, cell survival, synaptogenesis, oxidation, metabolism. These results support hypothesis that OS dysfunction may play a pivotal role age-associated diseases, can serve as potential clinical targets future therapy.