Relationship Between β-Cell Function, Metabolic Control, and Microvascular Complications in Type 2 Diabetes Mellitus

• DOI: 10.1089/dia.2014.0214
• Publication Date: 2015-01-09T19:10:39Z
• Authors: Lihua Zhao; Jing Ma; Shaoxin Wang; Yun Xie
• Keywords: C-peptide

This study investigated the relationship among β-cell function, metabolic control, and diabetic microvascular complications in patients with type 2 diabetes mellitus (T2DM).In total, 885 (DM) were recruited from January 2012 to 2014 grouped into three groups according area under curve of C-peptide [AUC(C-pep)] during 75-g oral glucose tolerance test. Logistic regression analyses used evaluate association between complications.The prevalence decreased first third AUC(C-pep) tertile (P < 0.01 for all), whereas rates nonalcoholic fatty liver disease (NAFLD) was positively associated values. Patients lower exhibited higher levels glycosylated hemoglobin high-density lipoprotein cholesterol longer duration DM; however, triglycerides, fasting C-peptide, 2-h body mass index, homeostasis model assessment insulin resistance index compared tertile. Comparison a similar DM showed level inversely complications. The odds ratios nephropathy, retinopathy, neuropathy lowest versus highest 3.10 (95% confidence interval, 2.01-4.78), 2.83 (1.73-4.64), 2.04 (1.37-3.04) after adjustment confounding factors.Higher good glycemic endogenous linked components syndrome increased NAFLD.