MiniMed 780G Six-Month Use in Children and Adolescents with Type 1 Diabetes: Clinical Targets and Predictors of Optimal Glucose Control

• DOI: 10.1089/dia.2022.0491
• Publication Date: 2023-02-10T16:16:16Z
• Authors: Fortunato Lombardo; Stefano Passanisi; Angela Alibrandi; Bruno Bombaci; Riccardo Bonfanti; Maurizio Delvecchio; Francesca Di Candia; Enza Mozzillo; Elvira Piccinno; Claudia Anita Piona; Andrea Rigamonti; Francesco Scialabba; Claudio Maffeis; Giuseppina Salzano
• Keywords: Glycated hemoglobin; Concomitant

Background: The aim of this multicenter observational real-world study was to investigate glycemic outcomes in children and adolescents with type 1 diabetes over the first 6-month use MiniMed™ 780G. secondary objective evaluate demographic clinical factors that may be significantly associated achievement therapeutic goals. Methods: Demographic, anamnestic, data participants were collected at time enrollment. Data on ambulatory glucose profile acquired 3 6 months after activating automatic mode. Aggregated metrics device settings entire period analyzed identify predictors optimal control, assessed by concomitant range (TIR) >70%, coefficient variation (CV) <36%, management indicator (GMI) <7%, below (TBR) <4%. Results: Our cohort consisted 111 (54.1% female) aged 7-18 years. All most relevant targets achieved according recommendations from International Consensus both months. When considering aggregated data, primary goals terms TIR, CV, GMI, TBR achieved, respectively, 72.1%, 74.8%, 68.5%, 74.8% participants. In addition, 44 individuals (39.6%) concomitantly addressed all above targets. Regression analysis revealed older age, briefer duration disease, shorter active insulin significant control. Comparing two groups stratified glycated hemoglobin (HbA1c) mean value year preceding MiniMed 780G use, achieving observed subgroup lower HbA1c. Conclusions: highlights effectiveness safety pediatric population. More extensive personalized training advanced hybrid closed-loop should considered for younger people those long disease duration.