Weight Gain and Glycemic Control in Adults with Type 1 Diabetes in the T1D Exchange Registry

• DOI: 10.1089/dia.2023.0389
• Publication Date: 2024-03-06T08:00:25Z
• Authors: Ryan Bailey; Peter Calhoun; Satish K. Garg
• Keywords: Adult; Male; Blood Glucose; Glycated Hemoglobin; Diabetes Mellitus, Type 1; Insulin, Regular, Human; Humans; Insulin; Female; Glycemic Control; Registries; Weight Gain

Aim: The impact of weight gain on insulin dosage and glycemic control in adults with type 1 diabetes (T1D) aged 25 years older was investigated the T1D Exchange Registry participants. Methods: Participants were categorized into four groups based their change from registry enrollment to year 5: stable (−5 <5 lb), gained 5 <10 lb, 10 <20 or ≥20 lb. Those who lost >5 lb excluded. primary outcomes glucose control, as measured by glycosylated hemoglobin (HbA1c), total daily dose (TDD) at 5. Linear regression models used evaluate association between gain, HbA1c, TDD. Results: There 1969 participants included analyses. mean ± standard deviation age 45 13 years, 57% female, 92% White non-Hispanic. For those an HbA1c <8.0%, higher for compared a −5 (7.4% 1.1% vs. 7.2% 0.8%, respectively; P = 0.005). this cohort, TDD increased 49 61 29 U while decreased 27 44 (P < 0.001). Among ≥9.0%, statistically insignificant 8.4% 1.3% 9.2% 1.7% 0.09). Conclusion: Significant had good adequate associated modest deterioration despite increase Worsening may indicate resistance related significantly which insufficient maintain control.