Comprehensive Analysis of Expression and Prognostic Value of Selenoprotein Genes in Thyroid Cancer

• DOI: 10.1089/gtmb.2021.0123
• Publication Date: 2022-04-28T14:50:05Z
• Authors: Yang Zhao; Pu Chen; Hong-jun Lv; Yuan Wu; Shu Liu; Xueyang Deng; Bingyin Shi; Jiao Fu
• Keywords: Selenoprotein; KEGG; GPX3

Background: Low selenium levels are associated with an increased incidence and advanced stage of thyroid cancers (THCAs). In response to changes in levels, a hierarchy selenoprotein biosynthesis allows tissue-specific fine-tuning the 25 selenoproteins. To determine role individual selenoproteins on carcinogenesis, we carried out multiomic data mining study. Methods: The expression their correlations prognosis THCAs were analyzed using Oncomine, GEPIA, Kaplan-Meier plotter platforms. Co-expression analyses cBioportal database identify genes that correlated Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichments performed for identified as clinically significant. Results Discussion:DIO1, GPX3, SELENOO, SELENOP, SELENOS, SELENOV significantly downregulated poor prognoses. Biological processes including negative regulation growth angiogenesis enriched DIO1-positively DIO1-negatively genes, respectively. Many biological MAPK cascade GPX3-positively GPX3-negatively antitumor effects SELENOS might be attributed protection against endoplasmic reticulum (ER) stress. SELENOO was revealed ER stress, mitochondrial translation, telomere maintenance. SELENOV-correlated redox calcium ion homeostasis. Moreover, cell adhesion also shown negatively regulated by SELENOV, providing antimetastatic effect similar DIO1. Conclusion: This study explored distinct roles THCA pathogenesis, potential oncosuppressing 6