NUTF2 as a Prognostic Indicator and Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma

• DOI: 10.1089/gtmb.2022.0102
• Publication Date: 2022-12-28T21:27:45Z
• Authors: Peng Li; Xin Wen; Xiaoying Zhang; Fufang Wang; Dong Zhang; Hong Shang
• Keywords: 0303 health sciences; 03 medical and health sciences; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Gene Expression Profiling; Biomarkers, Tumor; Humans; Prognosis; SEC Translocation Channels

Aim: To identify genes associated with the prognosis of head and neck squamous cell carcinoma (HNSC) and potential molecular targets for therapy. Materials and Methods: Gene Expression Profiling Interactive Analysis, Human Protein Atlas, University of ALabama at Birmingham CANcer, LinkedOmics, cBioPortal, Cell Counting Kit 8, and polymerase chain reaction were used in this study. Results: The expression level of nuclear transport factor 2 (NUTF2) was elevated in HNSC tissues and was associated with poor prognosis in HNSC patients. NUTF2-targeted intervention inhibited the proliferation of HNSC cells. SEC61G, which was positively correlated with NUTF2, was decreased in HNSC cells with NUTF2 suppression. Conclusions: NUTF2 may be correlated with the prognosis and development of HNSC, laying the foundation for future studies on the potential role of NUTF2 in HNSC.