Otitis Media in Children with Down Syndrome Is Associated with Shifts in the Nasopharyngeal and Middle Ear Microbiotas

• DOI: 10.1089/gtmb.2023.0132
• Publication Date: 2023-07-31T13:36:17Z
• Authors: Christina L. Elling; Salina H. Goff; Scott D. Hirsch; Kaitlyn Tholen; Jennifer M. Kofonow; Danielle Curtis; Charles E. Robertson; Jeremy D. Prager; Patricia J. Yoon; Todd M. Wine; Kenny H. Chan; Melissa A. Scholes; Norman R. Friedman; Daniel N. Frank; Brian W. Herrmann; Regie Lyn P. Sant...
• Keywords: Ear disease

Background: Otitis media (OM) is defined as middle ear (ME) inflammation that usually due to infection. Globally, OM a leading cause of hearing loss and the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, poorer outcomes. However, date, no studies have investigated bacterial profiles children DS OM. Method: We aimed determine if there are differences composition or relative abundance individual taxa within ME nasopharyngeal (NP) microbiotas (n = 11) compared those without 84). sequenced 16S rRNA genes analyzed sequence data for diversity indices taxa. Results: Individuals demonstrated increased biodiversity their NP microbiotas. In was associated specific ME. Conclusion: Our findings suggest dysbioses contributes susceptibility controls. These influences regulation mucosal microbiota pathology.