Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals

• DOI: 10.1089/ham.2017.0147
• Publication Date: 2018-03-29T17:06:51Z
• Authors: Jeremy E. Orr; Erica C. Heinrich; Matea Djokic; Dillon Gilbertson; Pamela N. Deyoung; Cecilia Anza-Ramirez; Francisco C. Vill...; Frank L. Powell; Atul Malhotra; Tatum Simonson
• Keywords: Periodic breathing; Central sleep apnea; Oxygen Saturation; Acetazolamide; Hypoxic ventilatory response; Hypoxia

Orr, Jeremy E., Erica C. Heinrich, Matea Djokic, Dillon Gilbertson, Pamela N. Deyoung, Cecilia Anza-Ramirez, Francisco Villafuerte, Frank L. Powell, Atul Malhotra, and Tatum Simonson. Adaptive servoventilation as treatment for central sleep apnea due to high-altitude periodic breathing in nonacclimatized healthy individuals. High Alt Med Biol. 19:178–184, 2018. Aims: Central (CSA) is common at high altitude, leading desaturation disruption. We hypothesized that noninvasive ventilation using adaptive (ASV) would be effective stabilizing CSA altitude. Supplemental oxygen was evaluated comparison. Methods: Healthy subjects were brought from sea level 3800 m underwent polysomnography on three consecutive nights. Subjects each condition–No treatment, ASV, supplemental oxygen–in random order. The primary outcome the effect of ASV index (ODI). Secondary outcomes included saturation, arousals, symptoms, comparison oxygen. Results: Eighteen least two conditions. There a significant difference ODI across treatments. no statistical between (17.1 ± 4.2 vs. 10.7 2.9 events/hour; p > 0.17) saturation or arousal index. Compared with improved (16.5 4.5 events/hour 0.5 0.2 < 0.003), addition Conclusions: found not clearly efficacious controlling persons traveling m, whereas resolved CSA. Adjustment algorithm may improve efficacy. have utility acclimatized more modest altitudes.