Plasma Markers for Early Prediction of Radiation-Induced Myocardial Damage

• DOI: 10.1089/jir.2022.0226
• Publication Date: 2023-04-17T03:22:44Z
• Authors: Yuanyuan Tao; Pei Li; Chenglong Zhao; Zhengshuai Mu; Yang Li; Shuanghu Yuan; Yuchun Wei
• Keywords: Infiltration (HVAC)

There is no sensitive and effective method to predict radiation-induced myocardial damage (RIMD). The aim of this study was explore plasma biomarkers for early prediction RIMD after radiotherapy (RT) in lung cancer patients a rat model. Biomarker levels were measured samples collected before thoracic RT from 17 patients. For the animal model, single radiation dose 40 Gy delivered cardiac apex female Wistar rats. Control rats received sham irradiation (0 Gy). Dynamic biomarker detection histopathological analysis confirm performed up 6 months RT. In patients, caspase-3 concentration significantly increased (P = 0.0479), with increasing but nonsignificant trends observed caspase-1, CCL2, vascular endothelial growth factor (VEGF), interleukin-1β, IL-6 > 0.05). Changes caspase-3, VEGF, correlated mean heart < CCl-2, CCl-5, TGF-β1 elevated first week post-RT 0.05), which earlier than pathological changes. Myocardial tissue also showed significant macrophage infiltration at 1 month 0.01) fibrosis postradiation 0.0001). Macrophage CCL5, 3 weeks 2 post-RT. Increased VEGF detected RIMD-related changes, indicating their clinical potential as RIMD.