Then-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in anIn VivoModel of Amyloid-β-Induced Alzheimer's Disease

• DOI: 10.1089/jmf.2014.3292
• Publication Date: 2015-03-18T16:56:26Z
• Authors: Ji Yeon Choi; Jeong Min Lee; Dong Gu Lee; Sunghun Cho; Young-Ho Yoon; Eun Ju Cho; Sanghyun Lee
• Keywords: Male; 0301 basic medicine; Memory Disorders; Mice, Inbred ICR; Amyloid beta-Peptides; Plant Extracts; Brain; Kidney; Nitric Oxide; Antioxidants; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Cognition; Liver; Alzheimer Disease; Memory; Animals; Lipid Peroxidation; Cognition Disorders; Maze Learning; Fagopyrum; Phytotherapy

This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.