Quality of Life in Patients with Brain Metastases Treated with a Palliative Course of Whole-Brain Radiotherapy

• DOI: 10.1089/jpm.2006.0202
• Publication Date: 2007-05-01T14:23:26Z
• Authors: Megan Doyle; Nicole Marie Eve ...; Kathy Li; Emily Sinclair; Kelvin Lam; Grace Chan; Edward Chow; Elizabeth A. Barnes; Cyril Danjoux; May N. Tsao
• Keywords: Concordance; Whole brain radiotherapy; Proxy (statistics); Bonferroni correction; Concordance correlation coefficient; Brain tumor

Background: The primary objective of this study was to assess whether there an improvement in quality life for patients with brain metastases as measured 1 and 2 months after a course whole-brain radiotherapy. secondary the level agreement between patient proxy scores. Methods materials: Sixty their completed Functional Assessment Cancer Therapy-Brain (FACT-BR) questionnaire independently. Proxies were given instructions answer from patient's perspective. Quality-of-life assessments conducted at baseline, month, completion Paired t tests Bonferroni adjustment multiple comparisons calculated detect significant differences global quality-of-life Lin's concordance correlation coefficient ratings. Results: No difference detected overall At radiotherapy, trend toward worsening general specific There poor proxies all domains baseline. Conclusion: Proxy rating patients' showed