Inflammation and Cardiovascular Risk in Women with Preterm Labor

• DOI: 10.1089/jwh.2011.3013
• Publication Date: 2012-03-08T11:41:54Z
• Authors: Jose L. Bartha; Alvaro Fernández-...; Fernando Bugatto; Maria Antonia Faj...; Nieves González-G...; Blas Hervías-Viva...
• Keywords: Endothelial Dysfunction; Endothelial Activation; Intercellular adhesion molecule

Background: Women with a history of preterm delivery have about twice the normal risk cardiovascular disease (CVD). Mechanisms underlying this association are not well understood. The aim present study was to evaluate relationships between selected metabolic CVD factors and markers both systemic inflammation endothelial dysfunction in women spontaneous labor (sPL). Methods: This case-control university tertiary referral center. Forty pregnant sPL were compared 50 controls during gestation. Maternal serum triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), total cholesterol, glycemia, insulinemia, homeostasis model assessment (HOMA), leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble vascular cell adhesion molecule (sVCAM), intercellular (sICAM), selectin, myeloperoxidase (MPO) measured. Results: Gestational age at similar groups (31.56±3.14 weeks gestation vs. 31.27±2.14 gestation, p=0.62, for control groups, respectively). Body mass index (BMI) (21.72±2.99 23.56±3.80, p=0.01), all fractions (HDL-C 53.44±18.22 68.32±18.38, p=0.0003; LDL-C 125.71±35.56 142.15±36.07, p=0.03, 219.55±32.29 240.38±40.01, p=0.009) MPO (3.07±0.63 3.48±0.32, p=0.0009) significantly lower sPL. Serum levels IL-6 (0.61±0.46 0.33±0.46, p=0.007) ratio cholesterol/HDL-C (4.52±1.48 3.77±1.37, p=0.01) increased correlated each other (r=0.21, p=0.04). Logistic regression showed that best predictive (R2=0.36, p=0.001) included BMI cholesterol. Conclusions: A combination low maternal BMI, levels, high is related inflammation.