Randomized Intervention Trial to Decrease Bisphenol A Urine Concentrations in Women: Pilot Study

• DOI: 10.1089/jwh.2016.5746
• Publication Date: 2016-10-11T15:37:08Z
• Authors: Todd Hagobian; Allison Smouse; Mikaela Streeter; Chloe Wurst; Andrew Schaffner; Suzanne Phelan
• Keywords: Benzhydryl compounds; Endocrine disruptor; Paraben

Previous studies have shown that women higher concentrations of the endocrine disruptor bisphenol A (BPA), but an intervention to reduce BPA is lacking in women. To test hypothesis would decrease urinary over 3 weeks, 24 (mean ± standard deviation [SD]; 22.1 2.8 kg/m2 body mass index, 20.9 1.5 years) were randomly assigned or control.The included weekly face-to-face meetings exposures from food, cosmetics, and other packaged products. Women provided with BPA-free hygiene, glass food/water containers, daily self-monitored major sources BPA. Fasting urine creatinine concentrations, weight assessed at study entry after weeks.A significant (p = 0.04) treatment × time interaction effect was observed on creatinine-adjusted concentrations. From significantly decreased geometric mean by -0.71 ng/m, whereas control increased 0.32 ng/mL 0.04). Additionally, lost -0.28 0.44 kg, gained +1.65 0.74 kg 0.03). Changes not related 0.67).In this pilot study, a 3-week Future clinical trials are needed confirm these results examine whether similar positively impacts risk markers pathogenesis cardiovascular disease diabetes.