Tetracycline and Macrolide Co-Resistance in Streptococcus pyogenes: Co-Selection As a Reason for Increase in Macrolide-Resistant S. pyogenes?

• DOI: 10.1089/mdr.2004.10.231
• Publication Date: 2004-10-23T03:31:43Z
• Authors: Hans Ulrik K. Nie...; Anette M. Hammerum; Kim Ekelund; Didi Bang; Lars V. Pallesen; Niels Frimodt-Møller
• Keywords: Streptococcus Pyogenes; Macrolide Antibiotics

In Denmark, tetracycline resistance in Streptococcus pyogenes is frequent (>30%) whereas macrolide low (<5%). The aim of this study was to investigate the genetic background tetracycline- and macrolide-resistant S. (MRSP) correlation between use using international data. A total 133 MRSP isolates were received at Statens Serum Institut from nine Danish clinical microbiology laboratories between. November 2000, 2002. macrolide-resistance genes, erm(B), erm(A), mef(A) detected 46%, 18%, 32% tested isolates, respectively. 4% none MR genes detected. Tetracycline found 52% MRSP. encoded by either tet(M) or tet(O). erm(B) associated with tet(M). Sixteen different T types among Analysis importance antibiotic for development showed no alone (p = 0.15) but a significant 0.03) combination use. frequency mainly due erm genes. high macrolide-tetracycline coresistance many countries including hence must be considered as co-factor selection