Albumin Oxidation and Albumin Glycation Discordance During Type 2 Diabetes Therapy: Biological and Clinical Implications

• DOI: 10.1089/met.2023.0275
• Publication Date: 2024-05-02T18:19:18Z
• Authors: Madhumati S. Vais...; Namita Kumari; Sathyanarayana Sr...; Vinaya Simha; Patnam R. Krishna...; Padmanabhan Balaram; Navakanta Bhat
• Keywords: Centre for Nano Science and Engineering; 610; Molecular Biophysics Unit

Cys34 albumin redox modifications (reversible "cysteinylation" and irreversible "di/trioxidation"), besides being just oxidative stress biomarkers, may have primary pathogenetic roles to initiate and/or aggravate cell, tissue, vascular damage in diabetes. In an exploratory "proof-of-concept" pilot study, we examined longitudinal changes oxidation during diabetes therapy.