Cognitive Deficits Following Traumatic Brain Injury Produced by Controlled Cortical Impact

• DOI: 10.1089/neu.1992.9.11
• Publication Date: 2009-03-26T20:23:18Z
• Authors: ROBERT J. HAMM; C. EDWARD DIXON; DAPHNE M. GBADEBO; AMRITA K. SINGHA; LARRY W. JENKINS; BRUCE G. LYETH; RONALD L. HAYES
• Keywords: Brain damage

Traumatic brain injury produces significant cognitive deficits in humans. This experiment used a controlled cortical impact model of experimental to examine the effects on spatial learning and memory using Morris water maze task. Rats (n = 8) were injured at moderate level (6 m/sec, 1.5–2.0 mm deformation). Eight additional rats served as sham-injured control group. performance was assessed days 11–15 30–34 following injury. Results revealed that brain-injured exhibited (p < 0.05) both testing intervals. Since task is particularly sensitive hippocampal dysfunction, results present support hypothesis hippocampus preferentially vulnerable damage traumatic These demonstrate enduring analogous those observed after human