Biomechanical Analysis of Experimental Diffuse Axonal Injury

• DOI: 10.1089/neu.1995.12.689
• Publication Date: 2009-01-29T23:40:23Z
• Authors: DAVID F. MEANEY; DOUGLAS H. SMITH; DAVID I. SHREIBER; ALLISON C. BAIN; REID T. MILLER; DOUG T. ROSS; THOMAS A. GENNARELLI
• Keywords: Diffuse axonal injury; Animal model

The purpose of this paper is to present results from methodologies used in our laboratory that are targeted toward identifying specific brain injury thresholds. Results studying one form injury, diffuse axonal presented report. Physical models, or surrogates, the skull–brain complex estimate relationship between inertial loading and deformation. A porcine model developed with information these physical models earlier vitro tissue modeling studies, correlate histologic radiologic evidence predicted regions experimental theoretical analysis. These basis for developing improved tolerance levels, as well new means diagnostic treatment techniques injury. Key words: injury; models; animal levels