The Effect of Goreisan on the Prevention of Chronic Subdural Hematoma Recurrence: Multi-Center Randomized Controlled Study

• DOI: 10.1089/neu.2017.5407
• Publication Date: 2018-02-15T05:39:37Z
• Authors: Kosuke Katayama; Naoya Matsuda; Kiyohide Kakuta; Masato Naraoka; Atsuhito Takemura; Seiko Hasegawa; Kenichi Akasaka; Norihito Shimamura; Katsuhiro Itoh; Kenichiro Asano; Hiromu Konno; Hiroki Ohkuma
• Keywords: Chronic Subdural Hematoma; Clinical endpoint; Single Center

The relatively high rate of post-operative recurrence in the treatment chronic subdural hematoma (CSDH) is a significant problem. Goreisan an herbal medicine that exhibits hydragogue effect by inhibiting expression aquaporins, and its efficacy preventing CSDH has been suggested several case trials. This multi-center prospective randomized controlled trial was performed to investigate preventative goreisan on recurrence. Patients with symptomatic over 60 years old undergoing burr hole surgery were enrolled this study. patients randomly allocated control group or group, which oral administration (7.5 g daily) continued for 12 weeks. primary end-point at weeks secondary volume reduction rates computed tomography scan analyses not only all ages older than years, but also divided into those under 75 old. One hundred eighty followed analyzed (the n = 88; 92). considering low without difference. showed no Based results present study, larger-scale study including more cases necessary future confirm goreisan.