Neuron-Derived Plasma Exosome Proteins after Remote Traumatic Brain Injury

• DOI: 10.1089/neu.2019.6711
• Publication Date: 2019-08-23T11:04:34Z
• Authors: Edward J. Goetzl; Carrie B. Peltz; Maja Mustapic; Dimitrios Kapogia...; Kristine Yaffe
• Keywords: Enolase

To identify long-term effects of traumatic brain injury (TBI) on levels plasma neuron-derived exosome (NDE) protein biomarkers cognitive impairment (CI), plasmas were obtained from four groups older veterans, who matched for age and sex: no TBI or CI (n = 42), with 19), without 21), 26). The was sustained 12 to 74 years before the study in 75%. NDEs enriched by sequential precipitation anti-L1CAM antibody immunoabsorption, extracted quantified enzyme-linked immunosorbent assays. Chronic NDE known increase three months after TBI, including cellular prion (PrPc), synaptogyrin-3, P-T181-tau, P-S396-tau, Aβ42, interleukin (IL)-6, elevated significantly subjects had compared controls but CI. biomarker showed higher PrPc, not P-S396-tau IL-6, those acute claudin-5, annexin VII, aquaporin-4 increased either group which are distinctively may prove useful evaluating patients. Aβ42 P-tau species, as well their respective putative receptors, PrPc remain decades mediate TBI-associated be targets development drugs.