Genetic or Pharmacological Ablation of Acid-Sensing Ion Channel 1a (ASIC1a) Is Not Neuroprotective in a Mouse Model of Spinal Cord Injury

• DOI: 10.1089/neu.2022.0295
• Publication Date: 2023-03-16T09:41:25Z
• Authors: Victoria S. Foster; Natalie J. Saez; Ellen R. Gillespie; Trisha Jogia; Chantelle Reid; Snezana Maljevic; Woncheol Jung; Hong W. Lao; Marc J. Ruitenberg; Glenn F. King
• Keywords: Acid-sensing ion channel; Excitotoxicity

Acid-sensing ion channel 1a (ASIC1a) is a proton-activated that expressed ubiquitously throughout the central nervous system and in various types of immune cells. Its role spinal cord injury (SCI) controversial; inhibition ASIC1a has been reported to improve SCI pathology