Head Kinematics, Blood Biomarkers, and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock

• DOI: 10.1089/neu.2022.0338
• Publication Date: 2023-06-21T09:27:32Z
• Authors: Andrew R. Mayer; Andrew B. Dodd; Rebecca J. Dodd; David D. Stephenson; Josef M. Ling; Carissa J. Mehos; Declan A. Patton; Cidney R. Roberts...; Andrew P. Gigliotti; Meghan S. Vermillion; Alessio Noghero
• Keywords: Head trauma; Pathophysiology; Closed head injury

Traumatic brain injury (TBI) and severe blood loss resulting in hemorrhagic shock (HS) are each leading causes of mortality morbidity worldwide, present additional treatment considerations when they comorbid (TBI+HS) as a result competing pathophysiological responses. The current study rigorously quantified biomechanics with high precision sensors examined whether blood-based surrogate markers were altered general trauma well post-neurotrauma. Eighty-nine sexually mature male female Yucatan swine subjected to closed-head TBI+HS (40% circulating volume;