Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury

• DOI: 10.1089/neu.2023.0046
• Publication Date: 2023-08-08T12:58:32Z
• Authors: Aaron M. Gusdon; Jude PJ Savarraj; John B. Redell; Atzhiry Paz; Sarah Hinds; Angela Burkett; Glenda Torres; Xuefang Ren; Neeraj Badjatia; Georgene W. Herge...; Anthony N. Moore; H. Alex Choi; Pramod K. Dash
• Keywords: Glasgow Outcome Scale; Univariate analysis

Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and cell signaling. As can compromise integrity alter we sought to identify circulating phospholipid alterations after mTBI, determine if these changes were associated with clinical outcomes. Patients mTBI (Glasgow Coma Score [GCS] ≥13 loss consciousness <30 min) recruited. A total 84 subjects enrolled admission a level I trauma center, the majority having evidence intracranial hemorrhage on computed tomography (CT). Plasma samples collected within 24 h 32 returning at 3 months second sample be collected. Thirty-five healthy volunteers as controls had one-time blood draw. metabolomics was performed from each subject. Fold change selected lipid determined. Multivariable regression models created test associations between discharge 6-month Glasgow Outcomes Scale-Extended (GOSE) outcomes (dichotomized "good" [GOSE ≥7] "bad" ≤6] functional outcomes). levels 31 significantly GOSE using univariate models; three increased, while 14 decreased good compared poor In multivariable logistic models, higher lysophospholipids (LPL) 1-linoleoyl-glycerophosphocholine (GPC) (18:2), 1-linoleoyl-GPE 1-linolenoyl-GPC (18:3) both (odds ratio [OR] 12.2 [95% CI 3.35, 58.3],