Ventilatory Support, Extubation, and Cerebral Perfusion Changes in Pre-Term Neonates: A Near Infrared Spectroscopy Study

• DOI: 10.1089/neur.2023.0092
• Publication Date: 2024-04-11T18:47:33Z
• Authors: Paolo Massirio; Valentina Cardiello; Chiara Andreato; Samuele Caruggi; Marcella Battaglini; Andrea Calandrino; Giulia Polleri; Federica Mongelli; Mariya Malova; Diego Minghetti; Alessandro Parodi; Maria Grazia Calevo; Domenico Tortora; Andrea Rossi; Luca Antonio Rame...
• Keywords: extubation; RC86-88.9; Medical emergencies. Critical care. Intensive care. First aid; intraventricular hemorrhage; cerebral perfusion; 03 medical and health sciences; 0302 clinical medicine; NIRS; germinal matrix hemorrhage; Original Article; pre-term; NIRS; cerebral perfusion; extubation; germinal matrix hemorrhage; intraventricular hemorrhage; pre-term

Early extubation is considered to be beneficial for pre-term neonates. On the other hand, premature can cause lung derecruitment, compromised gas exchange, and need reintubation, which may associated with severe brain injury caused by sudden cerebral blood flow changes. We used near infrared spectroscopy (NIRS) investigate changes in oxygenation (rScO2) fractional tissue oxygen extraction (+) after infants. This a single-center retrospective study of NIRS data at time all consecutive neonates born our institution over 1-year period. Comparison between subgroups was performed. Nineteen patients were included; average gestational age (GA) 29.4 weeks. No significant change noted rScO2 cFTOE whole population. GA germinal matrix hemorrhage (GMH)-intraventricular (IVH) showed extubation. A increase previous GMH-IVH (+0.040; p = 0.05). To conclude, per se not perfusion. Patients diagnosed an cFTOE, suggesting perturbation perfusion further understanding during this challenging phenomenon. Larger studies are required corroborate findings.