Cytokine mRNA Expression Is Decreased in the Subplantar Muscle of Rat Paw Subjected to Carrageenan-Induced Inflammation after Low-Level Laser Therapy

• DOI: 10.1089/pho.2007.2119
• Publication Date: 2008-02-04T10:06:47Z
• Authors: Regiane Albertini; Antonio Balbin Vi...; Flavio Aimbire; Jan Bjordal; Aldo Brugnera; Josane Mittmann; Jose Antonio Silva; Maricilia Costa
• Keywords: Carrageenan

Objective: The objective of this work was to investigate the anti-inflammatory effects low-level laser therapy, applied at different wavelengths (660 and 684 nm), on cytokine mRNA expression after carrageenan-induced acute inflammation in rat paw. Background Data: Low-level therapy (LLLT) has been observed reduce pain inflammatory disorders. However, little is known about mechanisms behind effect or whether it wavelength-specific. Materials Methods: test sample consisted 32 rats divided into four groups: A1 (control-saline), A2 (carrageenan-only), A3 (carrageenan + 660 nm therapy), A4 therapy). animals from groups were irradiated 1 h induction by carrageenan injection. Continuous-wave red lasers with dose 7.5 J/cm2 used. Results: Both had 30%–40% lower for cytokines TNF-α, IL-1β, IL-6 paw muscle tissue than carrageenan-only control group. Cytokine measurements made 3 irradiation muscle, all differences between group LLLT statistically significant (p < 0.001). Conclusions: 660-nm 684-nm administered inflamed a levels within laser-irradiated tissue.