Low-Level Photobiomodulation Therapy Modulates H2O2 Production, TRPC-6, and PGC-1α Levels in the Dystrophic Muscle

• DOI: 10.1089/photob.2022.0115
• Publication Date: 2023-08-01T17:02:42Z
• Authors: Caroline Covatti; Daniela Sayuri Mi...; Guilherme Luiz da...; Heloina Nathalliê...; Caroline Caramano...; Adriana Pertille; Elaine Cristina L...; Elaine Minatel
• Keywords: Gastrocnemius muscle

Objective: This study evaluated photobiomodulation therapy (PBMT) effects on the factors involved in mitochondrial biogenesis, respiratory complexes, and transient receptor potential canonical channels (such as TRPC-1 TRPC-6) vitro (mdx muscle cells) vivo studies (gastrocnemius muscle) from mdx mice, dystrophin-deficient model of Duchenne muscular dystrophy (DMD). Background: There is no successful treatment for DMD, therefore demanding search new therapies that can improve role, quality life, survival dystrophic patients. Methods: The primary cells received PBMT at 0.6 J 5 J, gastrocnemius J. Results: treated with (0.6 J) showed cytotoxicity significantly lower levels hydrogen peroxide (H2O2) production. We also demonstrated, first time, capacity PBMT, a low dose J), reducing TRPC-6 content raising peroxisome proliferator-activated γ coactivator-1α (PGC-1α) muscle. Conclusions: modulates H2O2 production, TRPC-6, PGC-1α These results suggest laser could act an auxiliary