Long-Term Dietary Extra-Virgin Olive Oil Rich in Polyphenols Reverses Age-Related Dysfunctions in Motor Coordination and Contextual Memory in Mice: Role of Oxidative Stress

• DOI: 10.1089/rej.2012.1346
• Publication Date: 2012-09-05T18:43:04Z
• Authors: Vanessa Pitozzi; Michela Jacomelli; Dolores Catelan; Maurizio Servili; Agnese Taticchi; Annibale Biggeri; Piero Dolara; Lisa Giovannelli
• Keywords: Motor coordination; Mediterranean Diet; Olea

The aim of this study was to evaluate the effects olive oil phenols on brain aging in mice and verify whether antioxidant antiinflammatory activities these polyphenols were involved. C57Bl/6J fed from middle age senescence with extra-virgin (10% wt/wt dry diet) rich (total polyphenol dose/day, 6 mg/kg). Behavioral tests employed assess cognitive, motor, emotional behavior after or 12 months treatment. Parameters oxidative status inflammation measured different areas at same times evaluated for correlation behavioral changes. treatment improved contextual memory step-down test levels similar young animals prevented age-related impairment motor coordination rotarod test. This effect correlated reduced lipid peroxidation cerebellum (p<0.05), whereas did not correlate oxidation parameters. In conclusion, work points out that natural contained can improve some dysfunctions by differentially affecting areas. Such a modulation be obtained an intake is normal Mediterranean area, provided has sufficiently high content polyphenols.