Peroxiredoxin 5 Expression in the Human Thyroid Gland

• DOI: 10.1089/thy.2005.15.205
• Publication Date: 2005-03-22T16:56:29Z
• Authors: A.-C. Gérard; M.-C. Many; Ch. Daumerie; B. Knoops; I.M. Colin
• Keywords: Peroxiredoxin; Multinodular goitre

Peroxiredoxin 5 (PRDX5) is a newly discovered thioredoxin peroxidase able to reduce peroxides that implicated in antioxidant protective mechanisms. We report here its expression the human thyroid gland. Twentyseven specimens were examined by immunohistochemistry. They included six normal tissues, five multinodular goiters, nine hot nodules, two Hürthle cell adenomas, and thyroids from patients with Graves' disease. In control tissue, PRDX5 was heterogeneous, being stronger cubical functionally active follicular cells than flat quiescent thyrocytes. It diffuse cytoplasm, occasionally localized inclusions most likely corresponded mitochondria. This feature particularly marked adenoma case. thyroids, cytosolic labeling enhanced compared tissue signal also detected few nuclei. To determine whether level of different between goiters hyperthyroid immunoblotting performed these respective tissues. observed higher gland disease goiters. conclusion, our data show expressed where it could act as antioxidant. The directly correlated functional status epithelial cells, even more pronounced such