Utility of the Radioiodine Whole-Body Retention at 48 Hours for Modifying Empiric Activity of 131-Iodine for the Treatment of Metastatic Well-Differentiated Thyroid Carcinoma

• DOI: 10.1089/thy.2008.0339
• Publication Date: 2009-09-04T16:24:39Z
• Authors: Douglas Van Nostrand; Frank Atkins; Shari Moreau; Martha Aiken; Kanchan Kulkarni; Jingshu S. Wu; Kenneth D. Burman; Leonard Wartofsky
• Keywords: Dose

Background: Dosimetry has been used to help identify when empiric dosages of 131-I treatment for suspected metastatic well-differentiated thyroid carcinoma (WDTC) may be increased or should decreased, but dosimetry is complex, and easier approaches would useful. The three objectives this study were assess the utility percent whole-body retention at 48 hours (%WBR48hr) in identifying patients with WDTC whom therapeutic prescribed activity might increased/decreased, evaluate thresholds proposed by Sisson et al. 2003 increasing decreasing activity, determine relationship between %WBR48hr maximum tolerated (MTA). Method: A retrospective review was conducted who had WDTC, total thyroidectomy, disease, hormone withdrawal, dosimetry. determined based on Benua-Leeper protocol, four recommendations al., use evaluated relative an (EA) 7.4 GBq 131-I. biexponential equation from data. Results: Of 142 patients, 47 a <9%, all could have received more than EA average 21.0 (incremental range 6.8–23.2 GBq). Ten ≤ 5%, their safely least 250%. Conversely, if >24.8%, then 7 14 these exceeded MTA 0.37–3.18 GBq. Finally, > 40%, five six 0.85–3.18 regression presented. Conclusion: We conclude that, respect epithelial cell cancer, helps those decreased so as not exceed that al.'s published are applicable. favor model using lower limit threshold potentially useful method determining how much can decreased.