The Risk of Second Cancers After Diagnosis of Primary Thyroid Cancer Is Elevated in Thyroid Microcarcinomas

• DOI: 10.1089/thy.2011.0406
• Publication Date: 2012-12-13T16:37:16Z
• Authors: Christopher Kim; Xiaofeng Bi; Dongsheng Pan; Yingtai Chen; Tobias Carling; Shuangge Ma; Robert Udelsman; Yawei Zhang
• Keywords: Kidney cancer

Thyroid cancers have increased dramatically over the past few decades. Comorbidities may be important, and previous studies indicated elevated second cancer risk after initial primary thyroid cancers. This study examined of development a cancer, utilizing Surveillance, Epidemiology, End Results (SEER) program database.The cohort consisted men women diagnosed with first who were reported to SEER database in 1973-2008 (n=52,103). Standardized incidence ratios (SIR) calculated for all secondary Confidence intervals p-values are at 0.05 significance alpha level two-sided based on Poisson exact methods.In this cohort, 4457 individuals developed The developing varied from 10% 150% depending different types. Cancers sites, breast, skin, prostate, kidney, brain, salivary gland, thyroid, lymphoma, myeloma, leukemia elevated. magnitude by histology, tumor size, calendar year diagnosis, treatment cancer. was patients whose carcinomas small, or 1994, whom some form radiation administered.This large population-based analysis among suggests that there an increase most commonly gland kidney. Additionally, recently microcarcinomas (<10 mm) aggressive environment, genetic susceptibility,