Extrathyroidal Extension Is Associated with Compromised Survival in Patients with Thyroid Cancer

• DOI: 10.1089/thy.2016.0132
• Publication Date: 2016-09-05T23:41:36Z
• Authors: Linda M. Youngwirth; Mohamed A. Adam; Randall P. Scheri; Sanziana A. Roman; Julie A. Sosa
• Keywords: Lymphovascular invasion; Medullary Thyroid Cancer

Patients with thyroid cancer who have extrathyroidal extension (ETE) are considered to more advanced tumors. However, data on the impact of ETE patient outcomes remain limited. The purpose this study was evaluate association between and survival in patients cancer.The National Cancer Database (1998-2012) queried for all adult differentiated medullary cancer. were divided into three groups: no (T1 T2 tumors), minimal (T3 tumors <4 cm), extensive (T4 cm). Patient demographic, clinical, pathologic factors evaluated patients. A Cox proportional hazards model developed each histology identify associated survival.In total, 241,118 met inclusion criteria; 86.9% had ETE, 9.1% 4.0% ETE. Compared likely larger (1.4 cm vs. 1.8 2.0 cm, respectively), lymphovascular invasion (8.6% 28.0% 35.1%, positive margins after thyroidectomy (6.1% 35.2% 45.9%, regional lymph node metastases (32.5% 67.0% 74.6%, respectively; p < 0.01). After adjustment, (hazard ratio [HR] = 1.13; 0.01) (HR 1.74; compromised In 3415 87.9% 7.1% 5.0% (1.7 2.2 (19.2% 68.9% 79.3%, (5.8% 44.1% 51.9%, (39.0% 90.5% 94.4%, 1.63; cancer.In cancers, is survival. Given these findings, should be included treatment guidelines.