Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya

• DOI: 10.1089/vbz.2021.0024
• Publication Date: 2021-09-24T15:43:58Z
• Authors: Vincent Obanda; Bernard Agwanda; Isabel Blanco-Penedo; Irene Ann Mwangi; Edward King'ori; George P. Omondi; Clas Ahlm; Magnus Evander; Olivia Wesula Lwande
• Keywords: Seroprevalence

Crimean Congo Hemorrhagic Fever (CCHF) is an emerging tick-borne zoonotic viral disease with the potential of causing public health emergencies. However, less known about role wildlife and livestock in spreading virus. Therefore, we aimed to assess how interactions between African buffalo (Syncerus caffer) cattle may influence seroprevalence CCHF across livestock-wildlife management systems Kenya. The study included archived sera samples from only habitats (Lake Nakuru National Park Solio conservancy), open wildlife-livestock integrated (Maasai Mara ecosystem Meru Park), closed (Ol Pejeta Conservancy) We analyzed 191 139 using IDvet multispecies, double-antigen IgG enzyme-linked immunosorbent assay (ELISA). toward hemorrhagic fever virus (CCHFV) was significantly higher for compared (75.3% 28.1%, respectively, p < 0.001). obtained highest among 92.1% 28.8% 46.1% prevalence closed-integrated open-integrated systems, respectively. regression coefficients were all negative both system. Our results show that CCHFV circulates diverse animal community Kenya spatially disconnected foci. habitat overlap makes a "bridge species" or superspreader host increases transmission risks humans. effect system on depended tick control not per se. conclude buffalo, longer life span than livestock, reservoir serve as sentinel population longitudinal surveillance CCHFV.