Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.
0301 basic medicine
571
Base Sequence
Xenopus
Molecular Sequence Data
Fluorescent Antibody Technique
Membrane Proteins
Cell Communication
DNA
Cardiovascular System
Connexins
Peptide Fragments
Rats
03 medical and health sciences
Intercellular Junctions
Chemicals And Cas Registry Numbers
Electrochemistry
Oocytes
Animals
Amino Acid Sequence
Endothelium, Vascular
DOI:
10.1091/mbc.4.1.7
Publication Date:
2013-08-16T22:53:46Z
AUTHORS (4)
ABSTRACT
The cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 detected in the endothelium muscular as well elastic arteries punctate pattern consistent with known junctions. However, it not other cells vascular wall. By contrast, Cx43, another connexin present cardiovascular system, endothelial but abundant myocardium and aortic smooth muscle. We have tested ability these connexins to interact functionally. functionally expressed pairs Xenopus oocytes induced formation intercellular channels unique voltage dependence. Unexpectedly, communication did occur when expressing were paired those although each could connexin, Cx37, form oocytes. These findings indicate that establishment can be spatially regulated selective expression suggest mechanism may operate control extent between cells.
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