The Role of Myosin II in Glioma Invasion of the Brain

• DOI: 10.1091/mbc.e08-03-0319
• Publication Date: 2008-05-22T01:23:01Z
• Authors: Christopher Beadle; Marcela C. Assanah; Pascale Monzo; Richard Vallee; Steven S. Rosenfeld; Peter Canoll
• Keywords: Progenitor

The ability of gliomas to invade the brain limits efficacy standard therapies. In this study, we have examined glioma migration in living tissue by using two novel vivo model systems. Within brain, cells migrate like nontransformed, neural progenitor cells-extending a prominent leading cytoplasmic process followed burst forward movement cell body that requires myosin II. contrast, on two-dimensional surface, more fibroblasts, and they do not require II move. To explain phenomenon, studied through series synthetic membranes with defined pore sizes. Our results demonstrate A B isoforms are specifically required when has squeeze pores smaller than its nuclear diameter. They support which progenitor-like mode invasion requirement for represent an adaptation needed move within submicrometer effective size. Furthermore, absolute underscores importance molecular motor as potential target new anti-invasive therapies treat malignant tumors.