p120-Catenin Is a Key Component of the Cadherin–γ-Secretase Supercomplex

• DOI: 10.1091/mbc.e08-04-0394
• Publication Date: 2008-07-17T01:06:39Z
• Authors: Alexi Kiss; Regina B. Troyano...; Sergey M. Troyano...
• Keywords: Component (thermodynamics)

In this work, we show several previously unknown features of p120-catenin in a cadherin-catenin complex that are critical for our understanding cadherin-based adhesion and signaling. We human epithelial A-431 cells, nearly all p120 molecules engage high-affinity interaction with E-cadherin-catenin complexes located at the cellular surface. is positioned proximity to alpha-catenin cadherin. These findings suggest functional cooperation between adhesion. A low level cadherin-free molecules, contrast, could facilitate p120-dependent Finally, present compelling evidence key linker cementing transmembrane protease gamma-secretase. The cell-cell contact location supercomplex makes it an important candidate conducting different signals rely on gamma-secretase proteolytic activity.