Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells

• DOI: 10.1091/mbc.e09-04-0295
• Publication Date: 2009-10-01T01:57:58Z
• Authors: Sabrina Fritah; Edwige Col; Cyril Boyault; Jérôme Govin; Karin Sadoul; Susanna Chiocca; Elisabeth Christians; Saadi Khochbin; Caroline Jolly; Claire Vourc'h
• Keywords: Epigenome; HSF1; Heat shock factor; Histone deacetylase 2; Histone code

A major regulatory function has been evidenced here for HSF1, the key transcription factor of heat-shock response, in a large-scale remodeling cell epigenome. Indeed, upon heat shock, addition to its well-known transactivating activities, mediates genome-wide and massive histone deacetylation. Investigating underlying mechanisms, we show that HSF1 specifically associates with uses HDAC1 HDAC2 trigger this heat-shock-dependent This work therefore identifies as master regulator global chromatin acetylation reveals cross-talk between deacetylases general control genome organization response shock.