Plasma membrane tension regulates eisosome structure and function

• DOI: 10.1091/mbc.e19-04-0218
• Publication Date: 2019-12-18T17:38:44Z
• Authors: Daniel Appadurai; Lincoln Gay; Akshay Moharir; Michael J. Lang; Mara C. Duncan; Oliver Schmidt; David Teis; Thien N. Vu; Malan Silva; Erik M. Jorgensen; Markus Babst
• Keywords: Transport protein

Eisosomes are membrane furrows at the cell surface of yeast that have been shown to function in two seemingly distinct pathways, stress response and regulation nutrient transporters. We found many conditions affect both these pathways by changing plasma tension thus morphology composition eisosomes. For example, alkaline causes swelling an endocytic response, which together increase tension, thereby flattening The flattened eisosomes release transporters, aids their down-regulation. In contrast, glucose starvation or hyperosmotic shock shrinking, results slack deepening Deepened able trap transporters protect them from rapid endocytosis. Therefore, seem coordinate transporter stability.