Cell shape and intercellular adhesion regulate mitotic spindle orientation

• DOI: 10.1091/mbc.e19-04-0227
• Publication Date: 2019-08-14T14:51:42Z
• Authors: Jingchen Li; Longcan Cheng; Hongyuan Jiang
• Keywords: 0303 health sciences; Cell Polarity; Mitosis; Epithelial Cells; Articles; Spindle Apparatus; Models, Theoretical; Cadherins; 03 medical and health sciences; Cell Adhesion; Morphogenesis; Animals; Humans; Cell Shape; Cell Division

Cell division orientation plays an essential role in tissue morphogenesis and cell fate decision. Recent studies showed that either shape or adhesion geometry can regulate the of mitotic spindles thereby orientation. However, how they together spindle remains largely unclear. In this work, we use a general computational model to investigate competitive mechanism determining between intercellular epithelial cells. We find is dominated by when anisotropy small, but large. A strong moderate adhesive size ensure planar cells with large apico-basal elongation. also could be perpendicular region only one side adhered E-cadherin-coated matrix. But after compressed, governed will parallel Finally, demonstrate competition tricellular junctions effectively