The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast

• DOI: 10.1091/mbc.e19-05-0254
• Publication Date: 2019-09-25T16:24:15Z
• Authors: Katherine L. Schutt; James B. Moseley
• Keywords: Septin; Mitotic exit; Schizosaccharomyces

Animal and fungal cells divide through the assembly, anchoring, constriction of a contractile actomyosin ring (CAR) during cytokinesis. The timing position CAR must be tightly controlled to prevent defects in cell division, but many underlying signaling events remain unknown. conserved heterotrimeric protein phosphatase PP2A controls mitosis, upstream pathways including Greatwall–Ensa regulate activity. A role for regulation has been less clear, although loss yeast causes Here, we report that Sds23, an inhibitor family phosphatases, promotes symmetric division fission spatial control We found sds23∆ asymmetrically due misplaced followed by sliding away from its assembly site. These mutant exhibit delayed recruitment putative anchoring proteins glucan synthase Bgs1. Our observations likely reflect broader polarity cytokinesis because phenotypes were exacerbated when combined with mutations Ensa homologue, Igo1. results identify regulatory network as critical component coordinating