Spindle pole bodies function as signal amplifiers in the Mitotic Exit Network

• DOI: 10.1091/mbc.e19-10-0584
• Publication Date: 2020-05-18T13:31:14Z
• Authors: Ian W. Campbell; Xiaoxue Zhou; Angelika Amon
• Keywords: 0301 basic medicine; 03 medical and health sciences; Saccharomyces cerevisiae Proteins; Spindle Pole Bodies; Mitosis; Articles; Saccharomyces cerevisiae; Monomeric GTP-Binding Proteins; Signal Transduction

The signal transduction cascade, known as the mitotic exit network (MEN), detects nuclear position by scaffolding its GTPase onto the spindle pole body that moves into the daughter cell during anaphase. Propagating the MEN kinase cascade onto two spindle pole bodies amplifies MEN signaling, resulting in a timely exit from mitosis.