Myosin II and Arp2/3 cross-talk governs intracellular hydraulic pressure and lamellipodia formation

• DOI: 10.1091/mbc.e20-04-0227
• Publication Date: 2021-01-27T17:23:07Z
• Authors: Shivani Patel; Donna McKeon; Kimheak Sao; Changsong Yang; Nicole M. Naranjo; Tatyana M. Svitkina; Ryan J. Petrie
• Keywords: Myosin Type II; 0301 basic medicine; Cell Culture Techniques; Articles; Actomyosin; Fibroblasts; Actin-Related Protein 2-3 Complex; Extracellular Matrix; Actin Cytoskeleton; Cytoskeletal Proteins; 03 medical and health sciences; Cell Movement; Osmotic Pressure; Humans; Pseudopodia; rhoA GTP-Binding Protein; Signal Transduction

RhoA signaling can inhibit lamellipodia formation via two distinct pathways in high-pressure cells.