CLASP2 facilitates dynamic actin filament organization along the microtubule lattice

0301 basic medicine 0303 health sciences Microtubule-actin crosslinking Microtubules Actins Actin Cytoskeleton 03 medical and health sciences Humans Brief Reports Microtubule-Associated Proteins Actin CLASPs Cytoskeleton Protein Binding
DOI: 10.1091/mbc.e22-05-0149 Publication Date: 2023-01-04T16:50:44Z
ABSTRACT
CLASP2α directly cross-links multiple actin filaments to the microtubule lattice. CLASP2α-mediated cross-linking facilitates dynamic organization of actin filaments templated by microtubules. Furthermore, CLASP depletion results in disorganized actin fibers and reduced coalignment of actin fibers with microtubules, suggesting that microtubule–CLASP–actin interaction may influence overall cytoskeletal organization in cells.
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