CLASP2 facilitates dynamic actin filament organization along the microtubule lattice
0301 basic medicine
0303 health sciences
Microtubule-actin crosslinking
Microtubules
Actins
Actin Cytoskeleton
03 medical and health sciences
Humans
Brief Reports
Microtubule-Associated Proteins
Actin
CLASPs
Cytoskeleton
Protein Binding
DOI:
10.1091/mbc.e22-05-0149
Publication Date:
2023-01-04T16:50:44Z
AUTHORS (8)
ABSTRACT
CLASP2α directly cross-links multiple actin filaments to the microtubule lattice. CLASP2α-mediated cross-linking facilitates dynamic organization of actin filaments templated by microtubules. Furthermore, CLASP depletion results in disorganized actin fibers and reduced coalignment of actin fibers with microtubules, suggesting that microtubule–CLASP–actin interaction may influence overall cytoskeletal organization in cells.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (53)
CITATIONS (11)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....