Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway

• DOI: 10.1093/abbs/gmx076
• Publication Date: 2017-07-03T19:12:06Z
• Authors: Jian Wang; Jie Xu; Guoqiang Xing
• Keywords: Lycorine

Signal transducer and activator of transcription 3 (STAT3) is involved in the growth metastasis breast cancer, represents a potential target for developing new anti-tumor drugs. The purpose this study to investigate whether Lycorine, pyrrolo[de]phenanthridine ring-type alkaloid extracted from Amaryllidaceae genera, could inhibit cancer by targeting STAT3 signaling pathway. human cell lines were incubated with various concentrations proliferation, colony formation, cycle distribution, apoptosis, migration invasion assayed several vitro approaches. Results showed that Lycorine significantly suppressed invasion, as well induced but no apparent impact on cycle. In addition, effect tumor nude mouse models was investigated, results inhibited vivo. Mechanistically, phosphorylation transcriptional activity through upregulating SHP-1 expression. also downregulated expressions genes, including Mcl-1, Bcl-xL, MMP-2, MMP-9, which are apoptosis cancer. Taken together, these findings suggest may be promising candidate prevention treatment