Impact of frailty on health-related quality of life 1 year after transcatheter aortic valve implantation

• DOI: 10.1093/ageing/afaa071
• Publication Date: 2020-04-05T11:07:29Z
• Authors: Jeannette A Goudz...; Marjo J A G de Ro...; Fleurance E D van...; Eline H C Kwekkeboom; Mattie J Lenzen; Maarten P H van W...; Joris F W Ooms; Rutger-Jan Nuis; Nicolas M Van Mie...; Joost Daemen; Peter P T de Jaegere; Francesco U S Mat...
• Keywords: Frailty; Frail Elderly; Aortic Valve Stenosis; 3. Good health; Transcatheter Aortic Valve Replacement; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Risk Factors; Aortic Valve; Quality of Life; Humans; Prospective Studies; EMC COEUR-09; Research Paper; Aged

Abstract Background Transcatheter aortic valve implantation (TAVI) brings symptom relief and improvement in health-related quality of life (HRQoL) the majority patients treated for symptomatic, severe stenosis. However, there is a substantial group that do not benefit from TAVI. The aim this study to investigate impact frailty on HRQoL 1 year after Methods TAVI Care & Cure Program an ongoing, prospective, observational including referred our institution. A comprehensive geriatric assessment was performed evaluate existence using Erasmus Frailty Score (EFS). assessed EQ-5D-5 L at baseline Results 239 underwent completed Seventy (29.3%) were classified as frail (EFS ≥ 3). In non-frail patients, index did change (0.71(± 0.22) 0.68(± 0.33) points, P = 0.22); decreased 0.55(±0.26) 0.44 points (±0.33) (P 0.022). independent predictor deteriorated (OR 2.24, 95% CI 1.07–4.70, 0.003). absence peripheral artery disease 0.17, 0.05–0.50, 0.001) renal dysfunction 0.13, 0.04–0.41, <0.001) associated with improved Conclusion deterioration Notably, improve no arterial or impairment baseline.