Long-term fine particular exposure and incidence of frailty in older adults: findings from the Chinese Longitudinal Healthy Longevity Survey

• DOI: 10.1093/ageing/afad009
• Publication Date: 2023-02-16T10:59:30Z
• Authors: Yuebin Lv; Ze Yang; Lihong Ye; Meijie Jiang; Jinhui Zhou; Yanbo Guo; Yidan Qiu; Xinwei Li; Chen Chen; Aipeng Ju; Jun Wang; Chenfeng Li; Yang Li; Jiaonan Wang; Juan Zhang; John S Ji; Tiantian Li; Andrea A Baccarelli; Xu Gao; Xiaoming Shi
• Keywords: Healthy aging

The association between fine particular matter (PM2.5) and frailty is less studied, the national burden of PM2.5-related in China unknown.To explore PM2.5 exposure incident older adults, estimate corresponding disease burden.Chinese Longitudinal Healthy Longevity Survey from 1998 to 2014.Twenty-three provinces China.A total 25,047 participants aged ≥65-year-old.Cox proportional hazards models were performed evaluate adults. A method adapted Global Burden Disease Study was used calculate burden.A 5,733 incidents observed during 107,814.8 person-years follow-up. 10 μg/m3 increment associated with a 5.0% increase risk (Hazard Ratio = 1.05, 95% confidence interval [1.03-1.07]). Monotonic, but non-linear exposure-response, relationships observed, slopes steeper at concentrations >50 μg/m³. Considering interaction population ageing mitigation PM2.5, cases almost unchanged 2010, 2020 2030, estimations 664,097, 730,858 665,169, respectively.This nation-wide prospective cohort study showed positive long-term incidence. estimated indicated that implementing clean air actions may prevent substantially offset worldwide.