Call to action: a five nations consensus on the use of intravenous zoledronate after hip fracture

• DOI: 10.1093/ageing/afad172
• Publication Date: 2023-09-30T17:22:18Z
• Authors: Antony Johansen; Opinder Sahota; Frances Dockery; Alison J Black; Alasdair M J MacL...; M Kassim Javaid; Emer Ahern; Celia L Gregson
• Keywords: Consensus; Bone Density Conservation Agents; Hip Fractures; zoledronate; 610; Guidelines; osteoporosis; Zoledronic Acid; 3. Good health; older people; 618; hip fracture; Humans; Ireland; secondary prevention; Osteoporotic Fractures

Abstract Currently in the UK and Ireland, after a hip fracture most patients do not receive bone protection medication to reduce the risk of refracture. Yet randomised controlled trial data specifically examining patients with hip fracture have shown that intravenous zoledronate reduces refracture risk by a third. Despite this evidence, use of intravenous zoledronate is highly variable following a hip fracture; many hospitals are providing this treatment, whilst most are currently not. A range of clinical uncertainties, doubts over the evidence base and practical concerns are cited as reasons. This paper discusses these concerns and provides guidance from expert consensus, aiming to assist orthogeriatricians, pharmacists and health services managers establish local protocols to deliver this highly clinically and cost-effective treatment to patients before they leave hospital, in order to reduce costly re-fractures in this frail population.