Use of a frailty index to identify potentially inappropriate prescribing and adverse drug reaction risks in older patients

• DOI: 10.1093/ageing/afv166
• Publication Date: 2015-12-19T05:30:48Z
• Authors: Shane Cullinan; Denis O'Mahony; David O'Sullivan; Stephen Byrne
• Keywords: Drug reaction; Adverse drug reaction

potentially inappropriate prescribing (PIP) is a significant problem in health care today. We hypothesise that if doctors were given single indicator of PIP and adverse drug reaction (ADR) risk on patient's prescription, it might stimulate them to review the medicines. suggest frailty index (FI) score may be such suitable indicator.to determine whether positive relationship exists between status, appropriateness their medications propensity develop ADRs. Compare this just using number patient takes as an PIP/ADR risk.a was constructed applied database. The associations FI score, instances prescription likelihood developing ADR determined Pearson correlation tests χ(2) tests.significant shown (R = 0.92). mean above which patients experienced at least one instance 0.16. Patients threshold twice likely experience (OR 2.6, P < 0.0001) 2.1, 0.0001). taking more than six 3 times PIP.an relevant clinical for critically assess presence ultimately prevent ADRs, especially when used tandem with takes.