Polycystic ovary syndrome and endometrial cancer risk: results from a nationwide cohort study

• DOI: 10.1093/aje/kwae061
• Publication Date: 2024-05-16T06:48:40Z
• Authors: C L B Frandsen; M Gottschau; B Nøhr; J H Viuff; T Maltesen; S K Kjær; A Jensen; P F Svendsen
• Keywords: Quartile

Most previous studies found an elevated risk of endometrial cancer among women with polycystic ovary syndrome (PCOS). However, these had highly varying methods for ascertainment PCOS diagnoses and limitations such as few exposed short follow-up. In this cohort study, we investigated the association between born in Denmark January 1, 1940, December 31, 1993 (n = 1 719 121). Data including covariates, were derived from nationwide registers. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) 95% CIs. A total 7862 cases identified during 23.7 years follow-up (IQR, 37.7-61.9). increased compared without (HR 3.02; CI, 2.03-4.49). The was premenopausal 5.82; 3.64-9.30), whereas no marked seen postmenopausal women. women, results limited by young age at end Mounting evidence reinforces need prevention early detection. This article is part a Special Collection on Gynecological Cancers.