Branched-chain Amino Acid Intake and the Risk of Diabetes in a Japanese Community: The Takayama Study

• DOI: 10.1093/aje/kwt112
• Publication Date: 2013-09-06T01:09:30Z
• Authors: C. Nagata; K. Nakamura; K. Wada; M. Tsuji; Y. Tamai; T. Kawachi
• Keywords: Lower risk

Dietary supplementation with branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, has shown potential benefits for the metabolic profile. However, higher blood BCAA levels have been associated insulin resistance. To our knowledge, there no study on dietary BCAAs risk of diabetes. We examined association between intake diabetes in a population-based cohort Japan. A total 13,525 residents Takayama City, Japan, who enrolled 1992 responded to follow-up questionnaire seeking information about 2002. Diet at baseline was assessed by means validated food frequency questionnaire. high terms percentage protein significantly decreased women after controlling covariates; hazard ratio highest tertile versus lowest 0.57 (95% confidence interval: 0.36, 0.90; P-trend = 0.02). In men, leucine marginally diabetes; 0.70 0.48, 1.02; 0.06). Data suggest that may be decrease